Endocrine Abstracts

Defective p27 function predisposes mice and rats to pheochromocytomas (PCC), and reduction of p27 repression is a feature of human PCCs. These findings suggest that p27 plays a role in PCC tumorigenesis. Recently, it was reported that p27 indirectly regulates gene transcription by associating with transcription factors (TF) and inhibiting gene transcription at specific promoters.We hypothesized that defective p27 promotes tumor formation in adrenomedulla...